NAT2 fast acetylator genotype is associated with an increased risk of lung cancer among never-smoking women in Taiwan.

doi:10.1016/j.canlet.2004.12.015

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 醫學檢驗暨生物技術學系暨碩士班 > 期刊論文 > Item 310902500/11897

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题名:	NAT2 fast acetylator genotype is associated with an increased risk of lung cancer among never-smoking women in Taiwan.
作者:	Chiou HL;Wu MF;Chien WP;Cheng YW;Wong RH;Chen CY;Lin TS;Lee H
贡献者:	中山醫學大學
关键词:	NAT2;CYP1A2;Never-smoking;Females;Lung cancer
日期:	2005-06
上传时间:	2015-08-03T08:22:32Z (UTC)
ISSN:	0304-3835
摘要:	The correlation between cooking oil fumes, containing relatively higher amounts of heterocyclic amines, and female lung cancer has been revealed. The association of genetic polymorphisms of CYP1A2 and NAT2, two major enzymes responsible for the metabolism of heterocyclic amines, with lung cancer has been investigated with inconclusive results. In this study targeted on never-smoking population with 162 lung cancer patients and 208 non-cancer controls, while the distributions of CYP1A2 phenotypes in lung cancer patients were comparable to that in controls, NAT2 fast acetylators had an OR of 2.44 (95% CI 1.40-4.23, P=0.002) and 2.56 (95% CI 1.37-4.80, P=0.003) for lung cancer in overall and female cases, respectively, but not in males. These results suggested never-smoking females with NAT2 fast acetylator were more prone to lung cancer and reflected the possibility that exposure to heterocyclic amines may contribute to the female lung cancer development in Taiwan.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11897 http://dx.doi.org/10.1016/j.canlet.2004.12.015
關聯:	Cancer Lett. 2005 Jun 1;223(1):93-101
显示于类别:	[醫學檢驗暨生物技術學系暨碩士班] 期刊論文

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