Ocimum gratissimum is effective in prevention against liver fibrosis in vivo and in vitro.

doi:10.1142/S0192415X14500530

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 醫學檢驗暨生物技術學系暨碩士班 > 期刊論文 > Item 310902500/11802

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題名:	Ocimum gratissimum is effective in prevention against liver fibrosis in vivo and in vitro.
作者:	Chiu YW;Chao PY;Tsai CC;Chiou HL;Liu YC;Hung CC;Shih HC;Lai TJ;Liu JY
貢獻者:	中山醫學大學
關鍵詞:	Collagen α;Hepatic Stellate Cells;Liver Fibrosis;Ocimum gratissimum: Oxidative Stress;α-SMA
日期:	2014
上傳時間:	2015-07-29T08:29:02Z (UTC)
ISSN:	0192-415X
摘要:	Ocimum gratissimum is a traditional herb commonly found in tropical regions, which prevents free radical damage and protects the liver from oxidative stress. In this study, we tested in vivo and in vitro the effectiveness of O. gratissimum extracts (OGEs) in anti-hepatic fibrosis in rats. Male Wistar rats were administered with carbon tetrachloride (CCl4) by intraperitoneal injection and varying amounts of oral injection of OGE doses (0-40 mg/kg body weight) for 8 weeks. Our experiments showed that OGE significantly reduced liver damage, including steatosis and fibrosis, in a dose-dependent manner, as well as significantly decreased the elevation in plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT). It also inhibited the formation of lipid peroxidative products during CCl4 treatment. Moreover, OGE-inhibited CCl4-induced liver collagen accumulation and promoted the expression of catalase, an anti-oxidative enzyme. The inhibition of fibrosis factors α-SMA expression was also observed. In primary cultures, OGE significantly inhibited the serum-induced activation of hepatic stellate cells (HSCs), and the expression of α-SMA and collagen α (I). These data suggest that O. gratissimum possesses anti-hepatic fibrosis properties via its anti-oxidative components.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11802 http://dx.doi.org/10.1142/S0192415X14500530
關聯:	Am J Chin Med. 2014;42(4):833-52
顯示於類別:	[醫學檢驗暨生物技術學系暨碩士班] 期刊論文

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