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https://ir.csmu.edu.tw:8080/ir/handle/310902500/11801
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| Title: | Anticancer effects of eleven triterpenoids derived from Antrodia camphorata. |
| Authors: | Lee, YP
Tsai, WC
Ko, CJ
Rao, YK
Yang, CR
Chen, DR
Yang, MH
Yang, CC
Tzeng, YM |
| Contributors: | 中山醫學大學 |
| Date: | 2012 |
| Issue Date: | 2015-07-29T08:22:54Z (UTC)
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| Abstract: | Eleven derivatives from Antrodia camphorata were isolated in order to evaluate their selective cytotoxicity toward 14 types of human cancer cell and two non-transformed cell types. Among these triterpenoids, methyl antcinate A (MAA) exhibited the most potent spectrum of anticancer effects in KB cells, four different oral cancer cell lines (TSCCa, GNM, OC-2, and OEC-M1), Panc-1, BT474, PC-3, OVCAR-3, HeLa, and U2OS cells with high selectivity indices (CC(50)/IC(50)). The expression of B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), and poly(ADP-ribose) polymerase (PARP) of PC-3 cells tested by western blotting suggested that MAA exerts cell death through the caspase-dependent cascade and the Bax-mediated mitochondrial apoptotic pathway, not only on liver and oral cancer cells but on other types as well, including prostate cancer, in a dose-dependent manner. In addition to MAA, methyl antcinate B, dehydroeburicoic acid, and 15α-acetyl-dehydrosulfurenic acid also exhibited significant selective cytotoxic effects to respective cancer cells. Modifications of these triterpenoids may lead to the development of more potent anticancer drugs.
PMID: 22753732 [PubMed - indexed for MEDLINE] |
| URI: | https://ir.csmu.edu.tw:8080/ir/handle/310902500/11801 |
| Relation: | Anticancer Res. 2012 Jul;32(7):2727-34. |
| Appears in Collections: | [醫學檢驗暨生物技術學系暨碩士班] 期刊論文
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