Relationship between adiponectin and leptin, and blood lipids in hyperlipidemia patients treated with red yeast rice.

doi:10.1159/000351455

中山醫學大學機構典藏 CSMUIR > 醫學院 > 免疫學研究所 > 期刊論文 > Item 310902500/11758

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11758

Title:	Relationship between adiponectin and leptin, and blood lipids in hyperlipidemia patients treated with red yeast rice.
Authors:	Lee, CY Jan, MS Yu, MC Lin, CC Wei, JC Shih, HC
Contributors:	中山醫學大學
Date:	2013
Issue Date:	2015-07-28T10:34:44Z (UTC)
ISSN:	1661-4119
Abstract:	BACKGROUND: This study aimed to investigate the possible relationships between adiponectin and leptin, blood lipids such as total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) as well as other clinical biomarkers in hyperlipidemia patients treated with red yeast rice. METHODS: 30 patients with primary hyperlipidemia were recruited, treated with red rice yeast capsules 600 mg twice a day for 8 weeks, and followed up for 4 weeks. The primary endpoint was the mean difference in LDL-C from baseline to week 8, while the secondary endpoints were the mean percentage changes from baseline of total cholesterol, TG, HDL-C, adiponectin, and leptin. RESULTS: At week 8, the decrease in LDL-C and total cholesterol was -38.11 ± 30.90 mg/dl (p < 0.0001) and -44.54 ± 27.46 mg/dl (p < 0.0001), respectively, and the increase in adiponectin was 35.83 ± 67.85 μg/ml (p = 0.017) as compared to baseline. Adiponectin also correlated positively with HDL-C (r2 = 0.39; p = 0.001). Serum leptin correlated negatively with TG (r2 = 0.19; p = 0.035), and there was a trend of correlation between leptin and HDL-C, but this was not statistically significant (r2 = 0.16; p = 0.052). CONCLUSION: Red yeast rice can significantly increase adiponectin and can significantly lower LDL-C and total cholesterol levels. Adiponectin correlates positively with HDL-C while serum leptin correlates negatively with TG. Red yeast rice has a potentially protective effect in obesity-related and cardiovascular diseases. © 2013 S. Karger GmbH, Freiburg.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11758 http://dx.doi.org/10.1159/000351455
Relation:	Forsch Komplementmed. 2013;20(3):197-203.
Appears in Collections:	[免疫學研究所] 期刊論文

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