中山醫學大學機構典藏 CSMUIR:Item 310902500/11748
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    题名: Pterostilbene induce autophagy on human oral cancer cells through modulation of Akt and mitogen-activated protein kinase pathway
    作者: Ko CP;Lin CW;Chen MK;Yang SF;Chiou HL;Hsieh MJ
    贡献者: 中山醫學大學
    关键词: Pterostilbene;Phytoalexin;Oral cancer;Apoptosis;Autophagy;MAPK
    日期: 2015-06
    上传时间: 2015-07-28T10:01:50Z (UTC)
    出版者: ScienceDirect
    ISSN: 1368-8375
    摘要: Objectives

    Extensive research supports the administration of herbal medicines or natural foods during cancer therapy. Pterostilbene, a naturally occurring phytoalexin, has various pharmacological activities, including antioxidant activity, cancer prevention activity, and cytotoxicity to many cancers. However, the effect of pterostilbene on the autophagy of tumor cells has not been clarified.

    Materials and methods

    In this study, the unique effects of pterostilbene on the autophagy of human oral cancer cells were investigated.

    Results

    The results of this study showed that pterostilbene effectively inhibited the growth of human oral cancer cells by inducing cell cycle arrest and apoptosis. In addition, the formation of acidic vesicular organelles and LC3-II production also demonstrated that pterostilbene induced autophagy. Administering 3-methylamphetamine (3-MA) and bafilomycin A1 (BafA1) exerted differing effects on the pterostilbene-induced death of human oral cancer cells. Pterostilbene-induced autophagy was triggered by activation of JNK1/2 and inhibition of Akt, ERK1/2, and p38.

    Conclusion

    In conclusion, this study demonstrated that pterostilbene caused autophagy and apoptosis in human oral cancer cells, suggesting that pterostilbene could serve as a new and promising agent for treating human oral cancer.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11748
    http://dx.doi.org/10.1016/j.oraloncology.2015.03.007
    關聯: Oral Oncology Volume 51, Issue 6, Pages 593–601
    显示于类别:[醫學檢驗暨生物技術學系暨碩士班] 期刊論文

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