Down-regulated expression of RhoA in human conventional renal cell carcinoma.

中山醫學大學機構典藏 CSMUIR > 醫學院 > 免疫學研究所 > 期刊論文 > Item 310902500/11712

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题名:	Down-regulated expression of RhoA in human conventional renal cell carcinoma.
作者:	Pu, YS Wang, CW Liu, GY Kuo, YZ Huang, CY Kang, WY Shun, CT Lin, CC Wu, WJ Hour, TC
贡献者:	中山醫學大學
关键词:	GTPase;renal cell carcinoma;real-time PCR;immunohistochemistry
日期:	2008
上传时间:	2015-07-28T05:22:50Z (UTC)
摘要:	BACKGROUND: Renal cell carcinoma (RCC) is the most common cancer in adult kidney. Delayed diagnosis may result in progression and metastasis. Markers for early detection of RCC are lacking. The small GTPase RhoA has been implicated in the regulation of cell morphology, motility and transformation, but the role of RhoA in tumorigenesis of RCC remains unclear. In this study, the significance of RhoA expression in human RCC was characterized. MATERIALS AND METHODS: RhoA mRNA and protein expressions were examined by real-time polymerase chain reaction (PCR) and immunohistochemistry respectively in 46 pairs of tissues. RESULTS: Real-time PCR revealed that RhoA mRNA expression was significantly lower in cancerous as compared to normal tissues (p = 0.036). RhoA protein expression was significantly higher in normal than in cancerous tissues (p = 0.032). However, RhoA expression did not correlate with age, differentiation grade or TNM stage (all p > 0.05). CONCLUSION: RhoA down-regulation may be involved in human renal tumorigenesis.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11712
關聯:	Anticancer Res. 2008 Jul-Aug;28(4B):2039-43.
显示于类别:	[免疫學研究所] 期刊論文

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