Beneficial effects of treatment with transglutaminase inhibitor cystamine on macrophage response in NZB/W F1 mice.

中山醫學大學機構典藏 CSMUIR > 醫學院 > 免疫學研究所 > 期刊論文 > Item 310902500/11674

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题名:	Beneficial effects of treatment with transglutaminase inhibitor cystamine on macrophage response in NZB/W F1 mice.
作者:	Hsu, TC Chiang, SY Huang, CY Tsay, GJ Yang, CW Huang, CN Tzang, BS
贡献者:	中山醫學大學
关键词:	systemic lupus erythematosus (SLE);matrix metalloproteinase (MMP);transglutaminase 2 (TG2);cystamine
日期:	2007
上传时间:	2015-07-27T09:48:30Z (UTC)
摘要:	Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disorder of unknown etiology. However, the definitive mechanisms remain obscure. Recently, transglutaminase 2 (TG2) was implicated in the pathogenesis of SLE. Cystamine, which inactivates TG2 activity by forming a mixed disulfide, may interfere with and inhibit other thiol-dependent enzymes such as caspases. To investigate the effects of cystamine in SLE pathogenesis, this in vivo study assessed the serum and macrophage response after administration of cystamine to NZB/W F(1) mice. The experimental results demonstrated for the first time a significant reduction in TG2 and matrix metalloproteinase (MMP)-9 activity; tissue inhibitor of metalloproteinases (TIMP)-1, TIMP-2, TG2, tumor necrosis factor alpha, and tumor growth factor beta mRNA expression; and anticardiolipin autoantibodies (aCL) in NZB/W F(1) mice following cystamine administration. It strongly suggests the therapeutic potential of cystamine in SLE.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11674
關聯:	Exp Biol Med (Maywood). 2007 Feb;232(2):195-203.
显示于类别:	[免疫學研究所] 期刊論文

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