Significant association of past parvovirus B19 infection with cytopenia in both adult-onset Still's disease and systemic lupus erythematosus patients.

doi:10.1016/j.cca.2012.01.027

中山醫學大學機構典藏 CSMUIR > 醫學院 > 免疫學研究所 > 期刊論文 > Item 310902500/11648

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11648

Title:	Significant association of past parvovirus B19 infection with cytopenia in both adult-onset Still's disease and systemic lupus erythematosus patients.
Authors:	Chen, DY Chen, YM Lan, JL Tzang, BS Lin, CC Hsu, TC
Contributors:	中山醫學大學
Keywords:	Human parvovirus B19 (B19);VP1-unique region protein (VP1u);Nonstructural protein-1 (NS1);Cytopenia;Arthritis;Adult-onset Still's disease (AOSD)
Date:	2012
Issue Date:	2015-07-27T08:21:57Z (UTC)
ISSN:	0009-8981
Abstract:	BACKGROUND: Human parvovirus B19 (B19) infection has been reported as a possible cause of autoimmune diseases. The association of B19 infection with adult-onset Still's diseases (AOSD) remains unclear. METHODS: IgM and IgG against B19-VP1/2 were determined using ELISA in 86 patients with AOSD, 58 patients with systemic lupus erythematosus (SLE) and 64 healthy controls. Anti-B19-VP1-unique region (VP1u) and anti-B19-nonstructural protein-1(NS1) antibodies were assessed by Western blot. B19 DNA was detected by nested PCR. RESULTS: Forty-three (50.0%) of 86 AOSD patients, 27 (46.6%) of 58 SLE patients and 30 (46.9%) of 64 controls had positivity for anti-B19-VP1/2-IgG in the absence of anti-B19-VP1/2-IgM, indicating past infection. None of enrolled subjects had detectable circulating B19 DNA. Significantly higher positivity rates for anti-B19-VP1u and anti-B19-NS1 IgG were observed in AOSD patients (39.5% and 46.5% respectively) and SLE patients (34.5% and 36.2% respectively) than in healthy controls (14.1%, p<0.005 for AOSD and p<0.05 for SLE, and 15.6%, p<0.001 for AOSD and p<0.05 for SLE; respectively). AOSD patients and SLE patients with seropositive results for anti-B19-VP1/2 IgG, anti-B19-VP1u or anti-B19-NS1 antibodies had a higher frequency of leucopenia and thrombocytopenia when compared to those with seronegative results. AOSD patients with anti-B19-VP1u or anti-B19-NS1 antibodies were more likely to have arthritis in comparison with those without these antibodies. CONCLUSIONS: Higher seroreactivity for anti-B19-VP1u and anti-B19-NS1 IgG were associated with cytopenia in both AOSD and SLE patients with unique correlation to arthritis in the AOSD. Further studies are necessary to determine if these responses correlate with a common genetic risk in patients with AOSD and SLE. Copyright © 2012 Elsevier B.V. All rights reserved.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11648 http://dx.doi.org/10.1016/j.cca.2012.01.027
Relation:	Clin Chim Acta. 2012 May 18;413(9-10):855-60.
Appears in Collections:	[免疫學研究所] 期刊論文

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