中山醫學大學機構典藏 CSMUIR:Item 310902500/11542
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    題名: Effect of black-pigmented bacteria on the plasminogen-plasmin system in human pulp and osteoblastic cells.
    作者: Yang, SF
    Hsieh, YS
    Huang, FM
    Yang, LC
    Chang, YC
    貢獻者: 中山醫學大學
    日期: 2003
    上傳時間: 2015-07-22T08:05:41Z (UTC)
    ISSN: 1079-2104
    摘要: OBJECTIVE:
    To date, there have been relatively few studies addressing the presence and expression of the plasminogen-plasmin system at the site of bacterial infection. The aim of the present study was to investigate the effect of black-pigmented bacteria on the expression of the plasminogen-plasmin system in human pulp and osteoblastic cells.
    STUDY DESIGN:
    The supernatants of Porphyromonas endodontalis, Porphyromonas gingivalis, and Prevotella intermedia were used to evaluate tissue-type plasminogen activator (t-PA) and type 1 plasminogen activator inhibitor (PAI-1) gene expression in human pulp and osteoblastic cells. The levels of mRNA were quantitatively measured by using reverse transcription-polymerase chain reaction.
    RESULTS:
    In this study, black-pigmented bacteria induced not only t-PA but also PAI-1 gene expression in human pulp and osteoblastic cells. In addition, the ratio of t-PA to PAI-1 was higher in human pulp and osteoblastic cells stimulated by black-pigmented bacteria than in untreated cell cultures (P <.05).
    CONCLUSIONS:
    A fine balance exists in the expression of components of the plasminogen-plasmin system, whereby tissue homeostasis is maintained. Black-pigmented bacteria activate the activator-inhibitor system in human pulp and osteoblastic cells through unbalance regulation of t-PA and PAI-1, which might result in an uncontrolled degradation of pulpal and periapical tissues.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11542
    http://dx.doi.org/10.1067/moe.2003.91
    關聯: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 May;95(5):621-5.
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