Alternation of cytosolic carbonic anhydrase isoenzymes during deciduomatal development in pregnant mice

doi:10.1016/j.fertnstert.2004.03.033

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/11527

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11527

Title:	Alternation of cytosolic carbonic anhydrase isoenzymes during deciduomatal development in pregnant mice
Authors:	Chiang, Whei-Ling Liu, Jer-Yuh Liao, Chu-Yu Yang, Shun-Fa Hsieh, Yih-Shou Chu, Shu-Chen
Contributors:	中山醫學大學
Keywords:	Carbonic anhydrases;deciduomata;substance P
Date:	2004
Issue Date:	2015-07-22T05:06:45Z (UTC)
ISSN:	0015-0282
Abstract:	Objective To analyze the activity of cytosolic carbonic anhydrases (CAs) during the pre- and postimplantation stages of pregnancy in mice. Furthermore, to investigate the CA activity in mice in which abortion was induced by injection of substance P. Design Controlled animal experiment. Setting University research laboratory. Animal(s) A total of 75 ICR mice (weight between 20–25 g) that showed two consecutive 4-day cycles. Intervention(s) Substance P (2.4 μg/g) or CA inhibitor (100 μg/g), or both, were administered. Decidualized uterine tissues were collected on days 0.5–10.5 after administration. Main outcome measure(s) The activity, protein expression pattern, and mRNA level of decidual cytosolic CAs. Results The abortion induced by injection of substance P led to an aberrant expression of cytosolic CA and a decreased number of embryos. Furthermore, substance P-induced abortion could be effectively inhibited by CA inhibitors. Conclusions Cytosolic CAs, especially CA II, may act as negative regulators in implantation, development, and maintenance of the pregnancy and therefore, this information could be further applied in developing therapies for human sterility.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11527 http://dx.doi.org/10.1016/j.fertnstert.2004.03.033
Relation:	Fertility and Sterility Volume 82, Supplement 3, October 2004, Pages 1095–1100
Appears in Collections:	[生化微生物免疫研究所] 期刊論文

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