Excessive matrix metalloproteinase-9 in the plasma of community-acquired pneumonia.

doi:10.1016/j.cccn.2004.09.025

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/11523

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题名:	Excessive matrix metalloproteinase-9 in the plasma of community-acquired pneumonia.
作者:	Yang, SF Chu, SC Chiang, IC Kuo, WF Chiou, HL Chou, FP Kuo, WH Hsieh, YS
贡献者:	中山醫學大學
关键词:	Matrix metalloproteinase-9;Community-acquired pneumonia;Neutrophils
日期:	2005
上传时间:	2015-07-22T04:50:29Z (UTC)
ISSN:	0009-8981
摘要:	It has been shown that matrix metalloproteinase-9 (MMP-9) is involved in the pathogenesis of various pulmonary inflammatory diseases. We determined the MMP-9 concentration in the plasma of community-acquired pneumonia (CAP) patients before and after antibiotic treatment. METHODS: Gelatin zymography and ELISA analysis were used to measure MMP-9 activity and MMP-9 level, respectively, in 35 control subjects and 46 CAP patients. RESULTS: WBC counts, neutrophils, MMP-9 activity and MMP-9 level were significantly higher in CAP patients compared with that of control subjects (P<0.001), while MMP-9 activity and MMP-9 level were returned to normal after the antibiotic treatment (P<0.001). In addition, MMP-9 level correlated positively with WBC counts and neutrophils number both before and after the antibiotic treatment. CONCLUSIONS: MMP-9 may play an important role in the pathogenesis of CAP with a positive correlation with the number of neutrophils.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11523 http://dx.doi.org/10.1016/j.cccn.2004.09.025
關聯:	Clin Chim Acta. 2005 Feb;352(1-2):209-15.
显示于类别:	[生化微生物免疫研究所] 期刊論文

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