Amphetamine, an appetite suppressant, decreases neuropeptide Y immunoreactivity in rat hypothalamic paraventriculum.

doi:10.1016/j.regpep.2004.11.007

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/11521

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题名:	Amphetamine, an appetite suppressant, decreases neuropeptide Y immunoreactivity in rat hypothalamic paraventriculum.
作者:	Hsieh, YS Yang, SF Kuo, DY
贡献者:	中山醫學大學
关键词:	Anorectic drug;Dopamine agonist;NPY;Orexigenic peptide;Clomipramine;Feeding behavior
日期:	2005
上传时间:	2015-07-22T04:46:24Z (UTC)
ISSN:	0167-0115
摘要:	Amphetamine (AMPH) is a well-known anorectic agent. The mechanism underlying the anorectic response of AMPH has been attributed to its inhibitory effect on hypothalamic neuropeptide Y (NPY), an orexigenic peptide in the brain. However, there is still lack of genomic or in situ immunohistochemical evidence to prove it. The present study was aimed to assess the molecular mechanism of AMPH anorexia by immunostaining of hypothalamic NPY protein in the area of paraventricular nucleus (PVN) and by detecting the change of hypothalamic NPY mRNA level using RT-PCR. Results revealed that an AMPH treatment might reduce the expression of NPY at both transcriptional and posttranslational levels. Comparatively, a treatment of clomipramine, a serotonin transporter inhibitor, was unable to reduce NPY mRNA level, revealing the noninvolvement of hypothalamic NPY gene in serotonin anorexia. Our results provided genomic and in situ immunohistochemical evidence to confirm the mediation of hypothalamic NPY neurons in the anorectic action of AMPH.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11521 http://dx.doi.org/10.1016/j.regpep.2004.11.007
關聯:	Regul Pept. 2005 Apr 15;127(1-3):169-76.
显示于类别:	[生化微生物免疫研究所] 期刊論文

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