Overexpression of protein kinase C alpha mRNA in human hepatocellular carcinoma: a potential marker of disease prognosis.

doi:10.1016/j.cca.2007.03.018

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/11492

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题名:	Overexpression of protein kinase C alpha mRNA in human hepatocellular carcinoma: a potential marker of disease prognosis.
作者:	Wu, TT Hsieh, YH Wu, CC Hsieh, YS Huang, CY Liu, JY
贡献者:	中山醫學大學
关键词:	Protein kinase Cα;Hepatocellular carcinoma
日期:	2007
上传时间:	2015-07-21T09:49:10Z (UTC)
ISSN:	0009-8981
摘要:	BACKGROUND: Members of the protein kinase C (PKC) isoenzyme family play a central role in the tumorigenesis of several tissues. However, little is known about subtype specific intracellular expression of PKC in human hepatocellular carcinomas. METHODS: We investigated PKC isoforms mRNA expression in 42 HCC specimens using reverse transcription polymerase chain reaction analysis, and the correlation between PKC isoforms expression and clinicopathologic parameters. RESULTS: We found that PKCalpha, PKCdelta and PKCiota mRNA were significantly increased in HCCs as compared to the corresponding non-cancerous liver tissues. PKCalpha expression also significantly correlated with tumor size (P<0.05) and TNM stage (P<0.05), but PKCdelta and PKCiota did not. The log-rank analysis revealed that patients with higher PKCalpha mRNA expression in the HCC tissues had significantly shorter survival rate than patients with lower PKCalpha mRNA expression (P<0.01). CONCLUSIONS: Our results suggested that the PKCalpha may be a prognostic factor for the survival of patients with HCC.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11492 http://dx.doi.org/10.1016/j.cca.2007.03.018
關聯:	Clin Chim Acta. 2007 Jul;382(1-2):54-8.
显示于类别:	[生化微生物免疫研究所] 期刊論文

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