Impact of serum levels and gene polymorphism of cytokines on chronic hepatitis C infection.

doi:10.1016/j.trsl.2007.01.007

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/11491

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11491

Title:	Impact of serum levels and gene polymorphism of cytokines on chronic hepatitis C infection.
Authors:	Chen, TY Hsieh, YS Wu, TT Yang, SF Wu, CJ Tsay, GJ Chiou, HL
Contributors:	中山醫學大學
Date:	2007
Issue Date:	2015-07-21T09:46:50Z (UTC)
ISSN:	1931-5244
Abstract:	The factors leading to clearance or persistent infection of hepatitis C virus (HCV) were not well defined, and the importance of the host immune response has been highlighted. Therefore, the impact of the serum concentration and genetic polymorphism of several cytokines on the outcome of HCV infection warrant additional study. Enzyme-linked immunosorbent assay was employed to measure serum tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-4, and IL-10 concentrations on 72 hepatitis C patients and 180 controls. Furthermore, the association between single nucleotide polymorphism (SNP) of genes of these cytokines and hepatitis C infection was evaluated by polymerase chain reaction- restriction fragment length polymorphism and statistical analysis. These analyzed SNPs of cytokines included TNF-alpha G238A, TNF-alpha G308A, IL-4 C589T, IL-10 A1082G, IL-10 T819C, and IL-10 A592C. Serum levels of TNF-mu alpha, IL-4, and IL-10 were significantly higher in hepatitis C patients than that of controls (P < 0.001). Furthermore, the distribution of TNF-alpha G308A genotypes and alleles, but not others, was statistically different between patients and controls (P < 0.05). These data suggested the distribution of polymorphism at TNF-alpha G308A may be different between normal subjects and patients with chronic infection of hepatitis C.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11491 http://dx.doi.org/10.1016/j.trsl.2007.01.007
Relation:	Transl Res. 2007 Aug;150(2):116-21.
Appears in Collections:	[生化微生物免疫研究所] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html	期刊論文	0Kb	HTML	337	View/Open

View Licence

Loading...