Luteolin induces apoptosis in oral squamous cancer cells.

doi:10.1177/154405910808700413

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/11474

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题名:	Luteolin induces apoptosis in oral squamous cancer cells.
作者:	Yang, SF Yang, WE Chang, HR Chu, SC Hsieh, YS
贡献者:	醫學研究所
关键词:	oral squamous cell carcinoma;SCC-4;luteolin;apoptosis
日期:	2008
上传时间:	2015-07-21T08:50:07Z (UTC)
ISSN:	0022-0345
摘要:	Oral squamous cell carcinoma is the most common malignancy of the oral cavity, and treatment approaches are inadequate. Luteolin, a natural flavonoid compound, has been shown to have anti-tumorigenic properties on various types of tumors. Therefore, we hypothesized that luteolin has anti-tumorigenic properties for oral squamous cell carcinoma, and may provide effective chemotherapy. Results revealed that luteolin reduced the viability of SCC-4 cells and induced apoptosis by decreasing the expression of cyclin-dependent kinase (CDKs), cyclins, and phosphor- retinoblastoma (p-Rb) anti-apoptotic protein, but increased the expression of pro-apoptotic proteins and activated caspase 9 and 3, with a concomitant increase in the levels of cleaved poly-ADP-ribose polymerase (PARP). Combination treatment of luteolin with paclitaxel enhanced the cytotoxic effect of paclitaxel in SCC-4 cells, and continuous administration of luteolin suppressed the growth of xenograft tumors in nude mice. These results suggest that luteolin could be an effective chemotherapeutic agent for the treatment of oral squamous cell carcinoma.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11474 http://dx.doi.org/10.1177/154405910808700413
關聯:	J Dent Res. 2008 Apr;87(4):401-6.
显示于类别:	[生化微生物免疫研究所] 期刊論文

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