Circulating matrix metalloproteinase-2 is associated with cystatin C level, posttransplant duration, and diabetes mellitus in kidney transplant recipients.

doi:10.1016/j.trsl.2007.12.004

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/11472

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11472

Title:	Circulating matrix metalloproteinase-2 is associated with cystatin C level, posttransplant duration, and diabetes mellitus in kidney transplant recipients.
Authors:	Chang, HR Kuo, WH Hsieh, YS Yang, SF Lin, CC Lee, ML Lian, JD Chu, SC
Contributors:	中山醫學大學
Date:	2008
Issue Date:	2015-07-21T08:41:32Z (UTC)
ISSN:	1931-5244
Abstract:	Studies have indicated that matrix metalloproteinase-2 (MMP-2) is vital for the patient's condition after renal transplantation. Although the allograft survival rate has been improved, the relationships between various clinical parameters in stable graft function and serum MMP-2 still need to be clarified. In this study, gelatin zymography and enzyme-linked immunosorbent assay were employed to measure MMP-2 level in the plasma of 152 kidney transplant recipients, 41 chronic kidney disease patients, and 50 healthy control subjects. The creatinine and the MMP-2 levels in the transplant recipients were significantly greater (P < 0.001) than those of control subjects. Univariate and stepwise regression analysis demonstrated the MMP-2 level was associated with cystatin C level (P < 0.001), creatinine level (P = 0.036), proteinuria (P = 0.043), posttransplant days (P = 0.025), and posttransplant diabetes mellitus (P = 0.03). We conclude that circulating MMP-2 is associated with cystatin C, posttransplant duration, and diabetes mellitus in kidney transplant recipients and suggest that MMP-2 may be critical for graft survival.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11472 http://dx.doi.org/10.1016/j.trsl.2007.12.004
Relation:	Transl Res. 2008 Apr;151(4):217-23.
Appears in Collections:	[生化微生物免疫研究所] 期刊論文

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