中山醫學大學機構典藏 CSMUIR:Item 310902500/11468
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    题名: Imbalanced serum concentration between cathepsin B and cystatin C in patients with pelvic inflammatory disease.
    作者: Tsai, HT
    Wang, PH
    Tee, YT
    Lin, LY
    Hsieh, YS
    Yang, SF
    贡献者: 中山醫學大學
    关键词: Cathepsin B;cystatin C;pelvic inflammatory disease
    日期: 2009
    上传时间: 2015-07-21T08:17:48Z (UTC)
    ISSN: 0015-0282
    摘要: OBJECTIVE:
    To detect the serum expression of cathepsin B and cystatin C and the ratio of cathepsin B to cystatin C in patients with pelvic inflammatory disease (PID) and speculate whether those are helpful indicators for the diagnosis of PID.
    DESIGN:
    A random consecutive study.
    SETTING:
    University hospital.
    PATIENT(S):
    Forty-four women who were diagnosed with PID.
    INTERVENTION(S):
    Collected blood specimens of patients before and after they received treatment.
    MAIN OUTCOME MEASURE(S):
    ELISA analysis was used to measure the serum levels of cathepsin B and cystatin C.
    RESULT(S):
    A significantly increased expression of cathepsin B but decreased expression of cystatin C and significant correlations between neutrophils and cathepsin B, as well as between C-reactive protein (CRP) and cathepsin B, were found in patients with PID. Consistently, the ratio of cathepsin B to cystatin C correlated significantly with neutrophils and with CRP in patients with PID.
    CONCLUSION(S):
    Increased expression of cathepsin B but a decreased level of cystatin C and an imbalance between cathepsin B and cystatin C may contribute to the progression of PID. Detection of cathepsin B and cystatin C can provide useful clinical information for PID.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11468
    http://dx.doi.org/10.1016/j.fertnstert.2007.12.076
    關聯: Fertil Steril. 2009 Feb;91(2):549-55.
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