Antimetastatic effects of Terminalia catappa L. on oral cancer via a down-regulation of metastasis-associated proteases.

doi:10.1016/j.fct.2010.01.019

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/11459

請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11459

題名:	Antimetastatic effects of Terminalia catappa L. on oral cancer via a down-regulation of metastasis-associated proteases.
作者:	Yang, SF Chen, MK Hsieh, YS Yang, JS Zavras, AI Hsieh, YH Su, SC Kao, TY Chen, PN Chu, SC
貢獻者:	中山醫學大學
關鍵詞:	Terminalia catappa;Invasion;Motility;Oral cancer;MMP-2;u-PA
日期:	2010
上傳時間:	2015-07-21T07:43:01Z (UTC)
ISSN:	0278-6915
摘要:	The incidence and mortality of oral cancer in Taiwan have been increased during the last decade, which could be mainly resulted from the difficulty in treatment related to metastasis. As a potential and popular folk medicine, Terminalia catappa leaves have been proven to possess various biological benefits including anti-cancer activities. However, the detailed effects and molecular mechanisms of T. catappa leaves on the metastasis of oral cancer cells were still unclear. Thus, SCC-4 oral cancer cells were subjected to a treatment with ethanol extracts of T. catappa leaves (TCE) and then analyzed for the effect of TCE on the migration and invasion. Modified Boyden chamber assays revealed that TCE treatment significantly inhibited the cell migration/invasion capacities of SCC-4 cells. Furthermore, results of zymography and western blotting showed that activities and protein levels of MMP-2, MMP-9 and u-PA were all inhibited by TCE. Further studies indicated that TCE may inhibit phosphorylation of ERK1/2, JNK1/2 and Akt while the expression of nuclear protein NF-kappaB, c-Jun and c-Fos were inhibited as well. EMSA assay revealed that the DNA-binding activity with AP-1 and NF-kappaB was also decreased by TCE. In conclusion, TCE may serve as a powerful chemopreventive agent against oral cancer metastasis. 2010 Elsevier Ltd. All rights reserved.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11459 http://dx.doi.org/10.1016/j.fct.2010.01.019
關聯:	Food Chem Toxicol. 2010 Apr;48(4):1052-8.
顯示於類別:	[生化微生物免疫研究所] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
index.html	期刊論文	0Kb	HTML	398	檢視/開啟

檢視Licence

在CSMUIR中所有的資料項目都受到原著作權保護.

TAIR相關文章

資料載入中.....