Antimetastatic effects of Terminalia catappa L. on oral cancer via a down-regulation of metastasis-associated proteases.

doi:10.1016/j.fct.2010.01.019

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/11459

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题名:	Antimetastatic effects of Terminalia catappa L. on oral cancer via a down-regulation of metastasis-associated proteases.
作者:	Yang, SF Chen, MK Hsieh, YS Yang, JS Zavras, AI Hsieh, YH Su, SC Kao, TY Chen, PN Chu, SC
贡献者:	中山醫學大學
关键词:	Terminalia catappa;Invasion;Motility;Oral cancer;MMP-2;u-PA
日期:	2010
上传时间:	2015-07-21T07:43:01Z (UTC)
ISSN:	0278-6915
摘要:	The incidence and mortality of oral cancer in Taiwan have been increased during the last decade, which could be mainly resulted from the difficulty in treatment related to metastasis. As a potential and popular folk medicine, Terminalia catappa leaves have been proven to possess various biological benefits including anti-cancer activities. However, the detailed effects and molecular mechanisms of T. catappa leaves on the metastasis of oral cancer cells were still unclear. Thus, SCC-4 oral cancer cells were subjected to a treatment with ethanol extracts of T. catappa leaves (TCE) and then analyzed for the effect of TCE on the migration and invasion. Modified Boyden chamber assays revealed that TCE treatment significantly inhibited the cell migration/invasion capacities of SCC-4 cells. Furthermore, results of zymography and western blotting showed that activities and protein levels of MMP-2, MMP-9 and u-PA were all inhibited by TCE. Further studies indicated that TCE may inhibit phosphorylation of ERK1/2, JNK1/2 and Akt while the expression of nuclear protein NF-kappaB, c-Jun and c-Fos were inhibited as well. EMSA assay revealed that the DNA-binding activity with AP-1 and NF-kappaB was also decreased by TCE. In conclusion, TCE may serve as a powerful chemopreventive agent against oral cancer metastasis. 2010 Elsevier Ltd. All rights reserved.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11459 http://dx.doi.org/10.1016/j.fct.2010.01.019
關聯:	Food Chem Toxicol. 2010 Apr;48(4):1052-8.
显示于类别:	[生化微生物免疫研究所] 期刊論文

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