中山醫學大學機構典藏 CSMUIR:Item 310902500/11444
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    题名: Impact of MCP-1 and CCR-2 gene polymorphisms on coronary artery disease susceptibility.
    作者: Lin, HL
    Ueng, KC
    Hsieh, YS
    Chiang, WL
    Yang, SF
    Chu, SC
    贡献者: 中山醫學大學
    关键词: MCP-1;CCR-2;Single nucleotide polymorphism;Coronary artery disease
    日期: 2012
    上传时间: 2015-07-21T05:22:44Z (UTC)
    ISSN: 0301-4851
    摘要: Coronary artery disease (CAD) was the second leading cause of death during the last 3 years in Taiwan. Smooth muscle cells, monocytes/macrophages, and endothelial cells produce monocyte chemoattractant protein-1 (MCP-1) within atherosclerotic plaques following binding to the chemokine receptor-2 (CCR-2). Previous studies have well-documented the association between MCP-1 expression and susceptibility to, or clinicopathological features, of CAD. This study investigated the relationships between MCP-1-2518A/G and CCR-2-V64I genetic polymorphisms and CAD in the Taiwanese population. A total of 608 subjects, including 392 non-CAD controls and 216 patients with CAD, were recruited and subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to evaluate the effects of these two polymorphic variants on CAD. Results indicated a significant association between MCP-1 -2548 gene polymorphism and susceptibility to CAD. GG genotypes (OR = 1.629; 95 % CI = 1.003-2.644), or individuals with at least one G allele (OR = 1.511; 95 % CI = 1.006-2.270), had a higher risk of CAD as compared with AA genotypes. Results also revealed that subjects with at least one A allele of the V64I CCR2 gene polymorphism had significantly increased risk of CAD. G allele in MCP-1-2518 might contribute to higher prevalence of atrial fibrillation in CAD patients (OR = 4.254; p < 0.05). In conclusion, MCP-1-2518G and CCR-2 64I gene polymorphisms represent important factors in determining susceptibility to CAD, and the contribution of MCP-1-2518G could be through effects on atrial fibrillation in CAD patients.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11444
    http://dx.doi.org/10.1007/s11033-012-1773-y
    關聯: Mol Biol Rep. 2012 Sep;39(9):9023-30.
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