Downregulated cardiac annexin VI mRNA and protein levels in chronically fibrillating human atria.

doi:10.1159/000106685

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/11256

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题名:	Downregulated cardiac annexin VI mRNA and protein levels in chronically fibrillating human atria.
作者:	Ueng, KC Lin, CS Yeh, HI Wu, YL Liu, RH Tsai, CF Tsai, TP Chen, SA
贡献者:	中山醫學大學
日期:	2008
上传时间:	2015-07-14T10:26:34Z (UTC)
ISSN:	0008-6312
摘要:	OBJECTIVES: We compared the expression and distribution of atrial annexin VI between patients with atrial fibrillation (AF) or sinus rhythm (SR). METHODS: Atrial appendages were obtained during cardiac surgery from 20 patients with chronic AF and 34 matched controls in SR. The expression and distribution of annexin VI were analyzed using semiquantitative RT-PCR, Western blotting and immunoconfocal microscopy. RESULTS: In the AF group, compared to SR, the mRNA was reduced to <35% and the protein to <50% in amount (for each atrium, all p < 0.01). Immunoconfocal microscopy confirmed the downregulation of annexin VI protein in AF and demonstrated the colocalization of annexin VI with both Na(+)/Ca(2+) exchangers and L-type Ca(2+) channels in the sarcolemma, but not with ryanodine receptors in the sarcoplasmic reticulum. CONCLUSIONS: Atrial annexin VI, spatially colocalized with both Na(+)/Ca(2+) exchangers and L-type Ca(2+) channels in the myocyte membrane, is downregulated during chronic AF. Copyright 2007 S. Karger AG, Basel.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11256 http://dx.doi.org/10.1159/000106685
關聯:	Cardiology. 2008;109(3):208-16. Epub 2007 Aug 27.
显示于类别:	[醫學系] 期刊論文

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