Evaluation of human osteosarcoma cell line genotoxicity effects of mineral trixoide aggregate and calcium silicate cements.

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题名:	Evaluation of human osteosarcoma cell line genotoxicity effects of mineral trixoide aggregate and calcium silicate cements.
作者:	Ding, SJ Kao, CT Chen, CL Shie, MY Huang, TH
贡献者:	中山醫學大學
日期:	2010
上传时间:	2015-07-10T07:51:51Z (UTC)
ISSN:	0099-2399
摘要:	INTRODUCTION: Mineral trioxide aggregate (MTA) and calcium silicate (CS) cements exhibit acceptable levels of cytocompatibility. The aim of the present study was to evaluate MTA and CS cement genotoxicity in a human osteosarcoma cell line (MG63). METHODS: A mitochondrial colorimetric assay was used to evaluate the MG63 survival rate. A DNA precipitation assay was used to detect the MG63 DNA damage after contact with MTA or CS cement extracts. RESULTS: The results showed that MTA and CS are cytocompatible with MG63 cells. There was no significant difference in the survival rate with MTA and CS materials (P > .05). Neither MTA nor CS cements causing MG63 cell DNA damage showed significant genotoxicity (P > .05). CONCLUSIONS: Both MTA and CS cements are compatible with MG63 cells, and they are not cancer-causing agents. Copyright 2010 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11132 http://dx.doi.org/10.1016/j.joen.2010.03.039
關聯:	J Endod. 2010 Jul;36(7):1158-62.
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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