中山醫學大學機構典藏 CSMUIR:Item 310902500/11124
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    题名: The effects of calcium silicate cement/fibroblast growth factor-2 composite on osteogenesis accelerator in human dental pulp cells
    作者: Wu, Buor-Chang
    Youn, Su-Chung
    Kao, Chia-Tze
    Huang, Shu-Ching
    Hung, Chi-Jr
    Huang, Tsui-Hsien
    Chou, Ming-Yung
    Shie, Ming-You
    贡献者: 中山醫學大學
    关键词: calcium silicate cement;endodontic material;fibroblast growth factor-2;osteogenesis;pulp cell
    日期: 2015
    上传时间: 2015-07-10T05:51:05Z (UTC)
    ISSN: 1991-7902
    摘要: Background/purpose

    To examine the effects of fibroblast growth factor-2 (FGF-2)/calcium silicate (CS) cement on material characters and in vitro primary human dental pulp cell (hDPC) behavior.

    Materials and methods

    Setting time and diametral tensile strength (DTS) of CS and CS/FGF-2 composite were measured. PrestoBlue assay was used for evaluating primary hDPC proliferation. Alkaline phosphatase and osteocalcin expression in HDPCs cultured on the specimens were determined by enzyme-linked immunosorbent assay. One-way analysis of variance was used to evaluate the significance of the differences between the mean values.

    Results

    Setting time and DTS of CS were not significantly different (P > 0.05) between CS hydration with H2O or FGF-2. Cell proliferation and osteogenic properties increased significantly (P < 0.05) with FGF-2 mixed CS. The CS/FGF-2 composite enhanced hDPC proliferation and osteogenic differentiation as compared to pure CS cement.

    Conclusion

    CS combined with FGF-2 is biocompatible with hDPCs. It not only promotes hDPC proliferation but also helps in differentiating reparative hard tissue. Thus, we suggest that the CS/FGF-2 composite has the potential for hard tissue defect repair.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11124
    http://dx.doi.org/10.1016/j.jds.2013.12.003
    關聯: Journal of Dental Sciences Volume 10, Issue 2, June 2015, Pages 145–153
    显示于类别:[牙醫學系暨碩士班] 期刊論文

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