Suppressive effect of carotenoid extract of Dunaliella salina alga on production of LPS-stimulated pro-inflammatory mediators in RAW264.7 cells via NF-κB and JNK inactivation

doi:10.1016/j.jff.2013.01.001

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/11036

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题名:	Suppressive effect of carotenoid extract of Dunaliella salina alga on production of LPS-stimulated pro-inflammatory mediators in RAW264.7 cells via NF-κB and JNK inactivation
作者:	Yang, Deng-Jye Linc, Jau-Tien Chen, Yi-Chen Liu, Shih-Chuan Lu, Fung-Jou Chang, Tien-Jye Wang, Meilin Lin, Hui-Wen Chang, Yuan-Yen
贡献者:	中山醫學大學
关键词:	Caroteinoid;Dunaliella salina;Pro-inflammatory mediator;NF-κB;JNK
日期:	2013
上传时间:	2015-07-03T04:43:33Z (UTC)
摘要:	The carotenoid extract from Dunaliella salina was used to evaluate the suppressive effects on lipopolysaccharide (LPS)-induced pro-inflammatory mediators in RAW264.7 cells. The extract composed all-trans forms of α-carotene (28.8 mg/g extract), β-carotene (471.1 mg/g extract), lutein (7.1 mg/g extract) and zeaxanthin (7.2 mg/g extract), 13- or 13′-cis-β-carotene (12.1 mg/g extract), 9- or 9′-cis-α-carotene (19.1 mg/g extract) and 9- or 9′-cis-β-carotene (440.3 mg/g extract) dose-dependently reduced the production of interleukin (IL)-1β, IL-6 and tumor necrosis factor-α (TNF-α), the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and the secretion of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-activated RAW264.7 cells. Its attenuation of LPS-induced inflammatory responses was closely related to inhibition of the nuclear NF-κB p50 subunit translocation by blocking inhibitor of κBα (IκB) phosphorylation and degradation correlated with suppressing IκB kinase (IKK) α/β phosphorylation, as well as down-regulation of the c-Jun NH2-terminal kinase (JNK) activation.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11036
關聯:	Journal of Functional Foods Volume 5, Issue 2, April 2013, Pages 607–615
显示于类别:	[生化微生物免疫研究所] 期刊論文

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