TARGETING THE IL-10 PATHWAY BY RNA INTERFERENCE HAS BENEFICIAL EFFECTS ON THE DEVELOPMENT OF EXPERIMENTAL LUPUS

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/11035

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题名:	TARGETING THE IL-10 PATHWAY BY RNA INTERFERENCE HAS BENEFICIAL EFFECTS ON THE DEVELOPMENT OF EXPERIMENTAL LUPUS
作者:	TSAY, G.J. HSIEH, Y-F. WANG, M. CHANG, D. CHANG, J.T. ZOUALI, M.
贡献者:	中山醫學大學
关键词:	IL-10;NZB/W mice;lupus
日期:	2013
上传时间:	2015-07-03T04:41:03Z (UTC)
摘要:	Results from patients with systemic lupus erythematosus (SLE) and from mice suffering from a lupus-like disease suggest that the IL-10 pathway is involved in pathogenesis, and that this cytokine could represent a target for managing SLE development. In this study, we constructed JC virus-like particles (VLP) expressing IL-10-specific short hairpin RNAs (shRNAs) that efficiently silenced IL-10 gene expression. In mice, a single injection of this preparation dramatically reduced serum levels of IL-IO. We tested the preventive effect of this vector expressing anti-IL-10 shRNAs in female (NZBxNZW) Fj mice. Weekly intraperitoneal injections decreased the incidence and severity of proteinuria, and prolonged lifespan, with reduced IL-10 production. Our data demonstrate that the IL-10 pathway plays a chief role in lupus pathogenesis. It indicates that JC virus-like particles represent a potent vector for delivering interfering RNA in vivo. They suggest that RNA interference targeting IL-10 is an effective strategy to silence the IL-10 pathway, and possesses a therapeutic potential that could be useful in the management of SLE and, possibly, other immune-mediated disorders.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11035
關聯:	European Journal of Inflammation (BIOLIFE, s.a.s.);Jan-Apr2013, Vol. 11 Issue 1, p43
显示于类别:	[生化微生物免疫研究所] 期刊論文

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