Diverse effects of parenteral arginine on systemic and local oxidant-antioxidant homeostasis and nitrosative stress in rats with subacute peritonitis.

doi:10.1016/j.jss.2013.10.002

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题名:	Diverse effects of parenteral arginine on systemic and local oxidant-antioxidant homeostasis and nitrosative stress in rats with subacute peritonitis.
作者:	Chen, YH CH, Lee CC, Hsiao Hsu, LS Lo, HC
贡献者:	中山醫學大學
关键词:	Antioxidant enzymes;Arginine;Lipid peroxidation;Nitric oxide;Nitrotyrosine;Parenteral nutrition;Peritonitis;Subacute peritonitis
日期:	2014
上传时间:	2015-07-02T09:22:54Z (UTC)
ISSN:	0022-4804
摘要:	BACKGROUND: The beneficial effects of arginine on oxidative stress have been previously reported; however, excess production of nitric oxide, an arginine metabolite, may cause hemodynamic instability and inflammatory response. Previous studies have demonstrated that parenteral arginine levels at 2%-4% of total calories may alleviate inflammation and enhance immunity, whereas greater than 6% of total calories may have adverse effects in rats with subacute peritonitis. Herein, we investigated the effects of parenteral arginine dose on lipid peroxidation (thiobarbituric acid reactive substances, TBARS) and antioxidant enzyme activities in the plasma and organs. MATERIALS AND METHODS: Male Wistar rats with cecal puncture-induced subacute peritonitis were infused with parenteral nutrition solutions containing 1.61% (CP group), 2.85% (LA group), 4.08% (MA group), and 6.54% (HA group) of total calories as arginine for 7 d. Healthy, orally fed rats (NC group) were used as references. RESULTS: Subacute peritonitis significantly elevated the levels of nitrate, nitrite and TBARS in the plasma and decreased glutathione peroxidase activity in the kidneys. These changes were significantly reversed in the MA and HA groups. The MA and HA groups had significantly increased nitrotyrosine levels in the plasma. The LA, MA, and HA groups had significantly increased glutathione peroxidase activity in the plasma, cytochrome P450 levels in the liver, and nitrotyrosine levels in the heart and had significantly decreased TBARS levels in the kidneys compared with the CP group. CONCLUSIONS: Our results suggest that parenteral arginine at a dose less than 4% of total calories may attenuate lipid peroxidation and increase antioxidant enzyme activities without leading to nitrosative stress in subacute peritonitis. Copyright © 2014 Elsevier Inc. All rights reserved.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10995 http://dx.doi.org/10.1016/j.jss.2013.10.002
關聯:	J Surg Res. 2014 Mar;187(1):134-41.
显示于类别:	[生化微生物免疫研究所] 期刊論文

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