Naringenin inhibits migration of bladder cancer cells through downregulation of AKT and MMP‑2.

doi:10.3892/mmr.2014.2375

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/10989

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题名:	Naringenin inhibits migration of bladder cancer cells through downregulation of AKT and MMP‑2.
作者:	Liao, AC Kuo, CC Huang, YC Yeh, CW Hseu, YC Liu, JY Hsu, LS
贡献者:	中山醫學大學附設醫院
日期:	2014
上传时间:	2015-07-02T09:02:46Z (UTC)
ISSN:	1791-2997
摘要:	Bladder cancer is one of the causes of cancer‑related death and has a high mortality rate due to its metastatic ability. Naringenin, a bioactive compound predominantly found in citrus fruits, exhibits several cellular functions, including anti‑oxidant, ‑lipidemia and ‑cancer abilities. However, the effects of naringenin on bladder cancer cells are yet to be elucidated. The present study investigated the molecular mechanisms underlying the effects of naringenin on the migration of TSGH‑8301 bladder cancer cells. Treatment with naringenin at doses ranging between 0 and 300 µM over a period of 24 h was found to reduce cell viability. Furthermore, zymography and western blot analysis revealed that naringenin reduced the expression of matrix metalloproteinase (MMP)‑2 in a dose‑dependent manner, and repressed its activity. Naringenin also reduced TSGH‑8301 cell migration in a concentration‑dependent manner, as evidenced by wound healing and Transwell® assays. In addition, naringenin was found to inhibit AKT activity and block the nuclear translocation of nuclear factor κ‑light‑chain‑enhancer of activated B cells. In conclusion, the findings of the present study show that naringenin is capable of inhibiting bladder cancer cell migration through the downregulation of the AKT and MMP‑2 pathways.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10989 http://dx.doi.org/10.3892/mmr.2014.2375
關聯:	Mol Med Rep. 2014 Sep;10(3):1531-6.
显示于类别:	[生化微生物免疫研究所] 期刊論文

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