Hibiscus protocatechuic acid inhibits lipopolysaccharide-induced rat hepatic damage.

doi:10.1007/s00204-002-0404-0

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/10820

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10820

Title:	Hibiscus protocatechuic acid inhibits lipopolysaccharide-induced rat hepatic damage.
Authors:	Lin, WL Hsieh, YJ Chou, FP Wang, CJ Cheng, MT Tseng, TH
Contributors:	中山醫學大學
Date:	2003
Issue Date:	2015-05-15T05:33:28Z (UTC)
ISSN:	0340-5761
Abstract:	Hibiscus protocatechuic acid (PCA), a phenolic compound found in the dried flowers of Hibiscus sabdariffa L. (Malvaceae), was demonstrated to have an antioxidant effect in vitro and in vivo, and an antitumor property in our previous study. In the present study, we used lipopolysaccharide (LPS, an endotoxin) to induce rat liver inducible nitric oxide synthase (iNOS), and found that pretreatment with PCA decreased the liver iNOS and the serum total nitrite induced by LPS. Our investigation showed that pretreatment of rats with PCA (0.2 and 0.5 mmol/kg dosed by gavage) for 5 days significantly decreased the serum levels of the hepatic enzyme markers alanine- and aspartate aminotransferase (ALT, alanine aminotransferase; AST, aspartate aminotransferase) induced by the 6-h treatment with LPS (i.p.; 5 mg/kg). Histopathological evaluation of the rat livers revealed that PCA reduced the incidence of liver lesions induced by LPS, including neutrophil infiltration, congestion, and liver cell swelling induced by LPS in rats. We conclude that PCA, an antioxidant, presents an inhibitory potential on iNOS and hepatic damage induced by LPS.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10820 http://dx.doi.org/10.1007/s00204-002-0404-0
Relation:	Arch Toxicol. 2003 Jan;77(1):42-7. Epub 2002 Nov 12.
Appears in Collections:	[生化微生物免疫研究所] 期刊論文

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