中山醫學大學機構典藏 CSMUIR:Item 310902500/10811
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    题名: Inhibitory effects of Hibiscus sabdariffa L extract on low-density lipoprotein oxidation and anti-hyperlipidemia in fructose-fed and cholesterol-fed rats
    作者: Chen, Chang-Che
    Chou, Fen-Pi
    Ho, Yung-Chyan
    Lin, Wea-Lung
    Wang, Chin-Pin
    Kao, Erl-Shyh
    Huang, An-Chung
    Wang, Chau-Jong
    贡献者: 中山醫學大學
    关键词: Hibiscus sabdariffa L;antioxidation;anti-hyperlipidaemia;triglyceride;high-fructose diet;high-cholesterol diet
    日期: 2004
    上传时间: 2015-05-15T04:49:08Z (UTC)
    ISSN: 0022-5142
    摘要: Hibiscus sabdariffa L extract (HSE) is an aqueous extract of Hibiscus sabdariffa L flowers that is used as a local soft drink and medical herb in Taiwan. Oxidation of low-density lipoprotein (LDL) has been shown to increase the incidence of atherosclerosis. In this study, we determined the antioxidative activity of HSE on LDL oxidation by examining relative electrophoretic mobilities (REM) and thiobarbituric acid-reactive substances (TBARS). The data revealed an inhibitory effect of HSE on Cu2+-mediated REM and TBARS. HSE exhibited a remarkable ability to reduce cholesterol degradation and ApoB fragmentation. Overall, HSE showed a high potency to inhibit the production of oxidized LDL induced by copper and, specifically, to reduce serum triglycerides in high-fructose diet (HFD) fed rats and serum cholesterol in high-cholesterol diet (HCD) fed animals. The levels of LDL and the ratio of LDL-cholesterol (LDL-C) to HDL-cholesterol (HDL-C) were reduced by HSE in both hyperlipidaemia models. Based on these findings, we suggest that HSE may be used to inhibit LDL oxidation and to prevent various types of hyperlipidaemia in HFD- or HCD-fed rats. Copyright © 2004 Society of Chemical Industry
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10811
    http://dx.doi.org/10.1002/jsfa.1872
    關聯: Issue Journal of the Science of Food and Agriculture
    显示于类别:[生化微生物免疫研究所] 期刊論文

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