Inhibitory effects of Hibiscus sabdariffa L extract on low-density lipoprotein oxidation and anti-hyperlipidemia in fructose-fed and cholesterol-fed rats

doi:10.1002/jsfa.1872

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/10811

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10811

Title:	Inhibitory effects of Hibiscus sabdariffa L extract on low-density lipoprotein oxidation and anti-hyperlipidemia in fructose-fed and cholesterol-fed rats
Authors:	Chen, Chang-Che Chou, Fen-Pi Ho, Yung-Chyan Lin, Wea-Lung Wang, Chin-Pin Kao, Erl-Shyh Huang, An-Chung Wang, Chau-Jong
Contributors:	中山醫學大學
Keywords:	Hibiscus sabdariffa L;antioxidation;anti-hyperlipidaemia;triglyceride;high-fructose diet;high-cholesterol diet
Date:	2004
Issue Date:	2015-05-15T04:49:08Z (UTC)
ISSN:	0022-5142
Abstract:	Hibiscus sabdariffa L extract (HSE) is an aqueous extract of Hibiscus sabdariffa L flowers that is used as a local soft drink and medical herb in Taiwan. Oxidation of low-density lipoprotein (LDL) has been shown to increase the incidence of atherosclerosis. In this study, we determined the antioxidative activity of HSE on LDL oxidation by examining relative electrophoretic mobilities (REM) and thiobarbituric acid-reactive substances (TBARS). The data revealed an inhibitory effect of HSE on Cu2+-mediated REM and TBARS. HSE exhibited a remarkable ability to reduce cholesterol degradation and ApoB fragmentation. Overall, HSE showed a high potency to inhibit the production of oxidized LDL induced by copper and, specifically, to reduce serum triglycerides in high-fructose diet (HFD) fed rats and serum cholesterol in high-cholesterol diet (HCD) fed animals. The levels of LDL and the ratio of LDL-cholesterol (LDL-C) to HDL-cholesterol (HDL-C) were reduced by HSE in both hyperlipidaemia models. Based on these findings, we suggest that HSE may be used to inhibit LDL oxidation and to prevent various types of hyperlipidaemia in HFD- or HCD-fed rats. Copyright © 2004 Society of Chemical Industry
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10811 http://dx.doi.org/10.1002/jsfa.1872
Relation:	Issue Journal of the Science of Food and Agriculture
Appears in Collections:	[生化微生物免疫研究所] 期刊論文

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