The efficacy of therapy with albendazole in mice with parasitic meningitis caused by Angiostrongylus cantonensis.

doi:10.1007/s00436-004-1105-9

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/10810

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10810

题名:	The efficacy of therapy with albendazole in mice with parasitic meningitis caused by Angiostrongylus cantonensis.
作者:	Lan, KP Lai, SC Wang, CJ Chen, KM Lee, SS Hsu, JD Lee, HH
贡献者:	中山醫學大學
日期:	2004
上传时间:	2015-05-15T04:43:32Z (UTC)
ISSN:	0932-0113
摘要:	Matrix metalloproteinase 9 (MMP-9) is involved in the pathogenesis of parasitic meningitis caused by the nematode Angiostrongylus cantonensis. The present study evaluated the efficacy of albendazole therapy in BALB/c mice infected with the third stage larvae of this nematode. Albendazole showed a pronounced larvicidal activity. Eosinophil numbers significantly increased in infected mice but decreased upon administration of albendazole. Densitometric scanning indicated that albendazole reduced gelatinolytic activity detected by gelatin-substrate zymography. In the cerebrospinal fluid, albendazole reduced the lytic area intensity of the 94 kDa MMP-9 band by 46.5% within 7 days, and by 51.5% by day 14. Examination of brain tissue revealed a similar pattern of decrease (48.6% by day 7, and 53.9% by day 14). Albendazole may thus be an effective compound for the treatment of angiostrongyliasis through its larvicidal activity and facilitation of an improved inflammatory response via the reduction of MMP-9 activity. Copyright 2004 Springer-Verlag
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10810 http://dx.doi.org/10.1007/s00436-004-1105-9
關聯:	Parasitol Res. 2004 Jul;93(4):311-7. Epub 2004 Jun 4.
显示于类别:	[生化微生物免疫研究所] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html	期刊論文	0Kb	HTML	427	检视/开启

检视Licence

在CSMUIR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....