Anti-inflammatory potential of flavonoid contents from dried fruit of Crataegus pinnatifida in vitro and in vivo.

doi:10.1021/jf040231f

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/10806

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题名:	Anti-inflammatory potential of flavonoid contents from dried fruit of Crataegus pinnatifida in vitro and in vivo.
作者:	Kao, ES Wang, CJ Lin, WL Yin, YF Wang, CP Tseng, TH
贡献者:	中山醫學大學
关键词:	Crataegus pinnatifida;macrophage;lipopolysaccharide;inducible nitric oxide synthase;cyclooxygenase-2
日期:	2005
上传时间:	2015-05-11T10:40:44Z (UTC)
ISSN:	0021-8561
摘要:	The dried fruits of Crataegus pinnatifida, a local soft drink material and medical herb, demonstrated antioxidant effect in a previous study. The present study investigates the anti-inflammatory potential of flavonoid contents from dried fruit of C. pinnatifida (CF-Fs). The preliminary investigation showed that CF-Fs (0.25-0.75 mg/mL) decreased the release of PGE2 and nitric oxide as induced by lipopolysaccharide (LPS, an endotoxin) in macrophage RAW 264.7 cells. The in vivo assay showed that pretreatment of rats with CF-Fs (50-200 mg/kg dosed by gavage) for 5 days significantly decreased the serum levels of the hepatic enzyme markers alanine aminotransferase and aspartate aminotransferase induced by the 6-h treatment with LPS (i.p.; 5 mg/kg). Histopathological evaluation of the rat livers revealed that CF-Fs reduced the incidence of liver lesions such as neutrophil infiltration and necrosis induced by LPS. Furthermore, it was found that pretreatment with CF-Fs decreased the hepatic expression of iNOS and COX-2 induced by LPS in rats. These results demonstrate that CF-Fs present anti-inflammatory potential in vitro and in vivo and that they may play a role in hepatoprotection.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10806 http://dx.doi.org/10.1021/jf040231f
關聯:	J Agric Food Chem. 2005 Jan 26;53(2):430-6.
显示于类别:	[生化微生物免疫研究所] 期刊論文

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