Hepatoprotective effects of Solanum nigrum Linn extract against CCl(4)-induced oxidative damage in rats.

doi:10.1016/j.cbi.2007.08.008

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/10771

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10771

题名:	Hepatoprotective effects of Solanum nigrum Linn extract against CCl(4)-induced oxidative damage in rats.
作者:	Lin, HM Tseng, HC Wang, CJ Lin, JJ Lo, CW Chou, FP
贡献者:	中山醫學大學
关键词:	Solanum nigrum Linn;Carbon tetrachloride;Liver fibrosis;Hepatoprotection
日期:	2008
上传时间:	2015-05-11T09:11:40Z (UTC)
ISSN:	0009-2797
摘要:	Solanum nigrum L. (SN) is an herbal plant that has been used as hepatoprotective and anti-inflammation agent in Chinese medicine. In this study, the protective effects of water extract of SN (SNE) against liver damage were evaluated in carbon tetrachloride (CCl4)-induced chronic hepatotoxicity in rats. Sprague-Dawley (SD) rats were orally fed with SNE (0.2, 0.5, and 1.0 g kg(-1) bw) along with administration of CCl4 (20% CCl4/corn oil; 0.5 mL kg(-1) bw) for 6 weeks. The results showed that the treatment of SNE significantly lowered the CCl4-induced serum levels of hepatic enzyme markers (GOT, GPT, ALP, and total bilirubin), superoxide and hydroxyl radical. The hepatic content of GSH, and activities and expressions of SOD, GST Al, and GST Mu that were reduced by CCl4 were brought back to control levels by the supplement of SNE. Liver histopathology showed that SNE reduced the incidence of liver lesions including hepatic cells cloudy swelling, lymphocytes infiltration, hepatic necrosis, and fibrous connective tissue proliferation induced by CCl4 in rats. Therefore, the results of this study suggest that SNE could protect liver against the CCl4-induced oxidative damage in rats, and this hepatoprotective effect might be contributed to its modulation on detoxification enzymes and its antioxidant and free radical scavenger effects.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10771 http://dx.doi.org/10.1016/j.cbi.2007.08.008
關聯:	Chem Biol Interact. 2008 Feb 15;171(3):283-93. Epub 2007 Aug 19.
显示于类别:	[生化微生物免疫研究所] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html	期刊論文	0Kb	HTML	340	检视/开启

检视Licence

在CSMUIR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....