Hepatoprotective effects of Solanum nigrum Linn extract against CCl(4)-induced oxidative damage in rats.

doi:10.1016/j.cbi.2007.08.008

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/10771

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10771

Title:	Hepatoprotective effects of Solanum nigrum Linn extract against CCl(4)-induced oxidative damage in rats.
Authors:	Lin, HM Tseng, HC Wang, CJ Lin, JJ Lo, CW Chou, FP
Contributors:	中山醫學大學
Keywords:	Solanum nigrum Linn;Carbon tetrachloride;Liver fibrosis;Hepatoprotection
Date:	2008
Issue Date:	2015-05-11T09:11:40Z (UTC)
ISSN:	0009-2797
Abstract:	Solanum nigrum L. (SN) is an herbal plant that has been used as hepatoprotective and anti-inflammation agent in Chinese medicine. In this study, the protective effects of water extract of SN (SNE) against liver damage were evaluated in carbon tetrachloride (CCl4)-induced chronic hepatotoxicity in rats. Sprague-Dawley (SD) rats were orally fed with SNE (0.2, 0.5, and 1.0 g kg(-1) bw) along with administration of CCl4 (20% CCl4/corn oil; 0.5 mL kg(-1) bw) for 6 weeks. The results showed that the treatment of SNE significantly lowered the CCl4-induced serum levels of hepatic enzyme markers (GOT, GPT, ALP, and total bilirubin), superoxide and hydroxyl radical. The hepatic content of GSH, and activities and expressions of SOD, GST Al, and GST Mu that were reduced by CCl4 were brought back to control levels by the supplement of SNE. Liver histopathology showed that SNE reduced the incidence of liver lesions including hepatic cells cloudy swelling, lymphocytes infiltration, hepatic necrosis, and fibrous connective tissue proliferation induced by CCl4 in rats. Therefore, the results of this study suggest that SNE could protect liver against the CCl4-induced oxidative damage in rats, and this hepatoprotective effect might be contributed to its modulation on detoxification enzymes and its antioxidant and free radical scavenger effects.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10771 http://dx.doi.org/10.1016/j.cbi.2007.08.008
Relation:	Chem Biol Interact. 2008 Feb 15;171(3):283-93. Epub 2007 Aug 19.
Appears in Collections:	[生化微生物免疫研究所] 期刊論文

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