Aqueous extract of Hibiscus sabdariffa L. decelerates acetaminophen-induced acute liver damage by reducing cell death and oxidative stress in mouse experimental models.

doi:10.1002/jsfa.3821

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/10754

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题名:	Aqueous extract of Hibiscus sabdariffa L. decelerates acetaminophen-induced acute liver damage by reducing cell death and oxidative stress in mouse experimental models.
作者:	Liu, LC Wang, CJ Lee, CC Su, SC Chen, HL Hsu, JD Lee, HJ
贡献者:	中山醫學大學
日期:	2010
上传时间:	2015-05-08T07:50:55Z (UTC)
ISSN:	0022-5142
摘要:	BACKGROUND: Acetaminophen (AAP)-induced oxidative stress can cause cell death to induce liver damage. The antioxidant effect of Hibiscus sabdariffa L. (HS) was shown in previous studies. In this study the effect of HS extract (HSE) on AAP-induced liver injury in BALB/c mice was investigated. RESULTS: In vivo, BALB/c mice were fed orally with 200, 400 or 600 mg kg(-1) HSE for 2 weeks and then injected with 1000 mg kg(-1) AAP. Pretreatment with HSE decreased lipid peroxidation and increased catalase activity and glutathione level. It also decreased AAP-induced liver injury, accompanied by decreased expression of pJNK, Bax and tBid in the liver. Additionally, HSE protected BALB/c normal liver cells from AAP-induced damage in vitro. CONCLUSION: It has been demonstrated that HSE can protect the mouse liver from AAP-induced injury and that the protective mechanism might involve decreasing oxidative stress and reducing cell death. (c) 2009 Society of Chemical Industry.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10754 http://dx.doi.org/10.1002/jsfa.3821
關聯:	J Sci Food Agric. 2010 Jan 30;90(2):329-37.
显示于类别:	[生化微生物免疫研究所] 期刊論文

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