Mulberry leaf extract inhibits the development of atherosclerosis in cholesterol-fed rabbits and in cultured aortic vascular smooth muscle cells.

doi:10.1021/jf305328d

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/10715

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10715

Title:	Mulberry leaf extract inhibits the development of atherosclerosis in cholesterol-fed rabbits and in cultured aortic vascular smooth muscle cells.
Authors:	Chan, KC Yang, MY Lin, MC Lee, YJ Chang, WC Wang, CJ
Contributors:	中山醫學大學
Keywords:	atherosclerosis;migration;mulberry leaf extract;proliferation
Date:	2013
Issue Date:	2015-05-04T09:58:54Z (UTC)
ISSN:	0021-8561
Abstract:	This study used high-cholesterol-fed New Zealand white rabbits and aortic vascular smooth muscle cells (VSMCs) to investigate the impact of mulberry leaf extract (MLE) on the development of atherosclerosis. The results show that the major components of MLE are polyphenols, flavonoids, carbohydrates, proteins, and lipids, and the major contituents of mulberry leaf polyphenol extract (MLPE) are polyphenols and flavonoids. In addition to improvement of liver function, the atheroma burden and levels of serum cholesterol, triglycerides, and low-density lipoprotein (LDL) are also significantly reduced after MLE treatment. MLE and MLPE improved endothelial function, inhibited proliferation and migration of aortic VSMCs, and reduced atheromas in the vascular wall. In conclusion, this study demonstrates that, in addition to exerting hypolipidemic effects, MLE and MLPE can effectively inhibit proliferation and migration of aortic VSMCs, improve vascular endothelial function, and reduce atheroma burden, thereby preventing atherosclerosis.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10715 http://dx.doi.org/10.1021/jf305328d
Relation:	J Agric Food Chem. 2013 Mar 20;61(11):2780-8.
Appears in Collections:	[生化微生物免疫研究所] 期刊論文

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