Hibiscus sabdariffa leaf polyphenolic extract inhibits LDL oxidation and foam cell formation involving up-regulation of LXRα/ABCA1 pathway.

doi:10.1016/j.foodchem.2013.03.026

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/10711

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题名:	Hibiscus sabdariffa leaf polyphenolic extract inhibits LDL oxidation and foam cell formation involving up-regulation of LXRα/ABCA1 pathway.
作者:	Chen, Jing-Hsien Wang, Chau-Jong Wang, Chi-Ping Sheu, Jenn-Yuan Lin, Chia-Liang Lin, Hui-Hsuan
贡献者:	中山醫學大學
关键词:	Low-density lipoprotein;Foam cells;Atherosclerosis;Hibiscus sabdariffa leaf;Polyphenol;Oxidation;Cholesterol removal
日期:	2013
上传时间:	2015-05-04T09:44:53Z (UTC)
ISSN:	0308-8146
摘要:	The oxidative modification of low-density lipoprotein (LDL) is involved in the pathogenesis of atherosclerotic lesions through the formation of macrophage-derived foam cells. In the present study, we aimed to investigate the anti-atherosclerotic effect of Hibiscus sabdariffa leaf polyphenolic extract (HLP), which is rich in flavonoid. The inhibitory effect of HLP on oxidation and lipid peroxidation of LDL was defined in vitro. HLP showed potential in reducing foam cell formation and intracellular lipid accumulation in oxidised-LDL (ox-LDL)-induced macrophage J774A.1 cells under non-cytotoxic concentrations. Molecular data showed these influences of HLP might be mediated via liver-X receptor α (LXRα)/ATP-binding cassette transporter A1 (ABCA1) pathway, as demonstrated by the transfection of LXRα siRNA. Our data implied that HLP up-regulated the LXRα/ABCA1 pathway, which in turn led to stimulation of cholesterol removal from macrophages and delay atherosclerosis. These results suggested that HLP potentially could be developed as an anti-atherosclerotic agent. Hibiscus sabdariffa leaf polyphenolic extract inhibits LDL oxidation and foam cell formation involving up-regulation of LXRα/ABCA1 pathway. - ResearchGate. Available from: http://www.researchgate.net/publication/239732517_Hibiscus_sabdariffa_leaf_polyphenolic_extract_inhibits_LDL_oxidation_and_foam_cell_formation_involving_up-regulation_of_LXRABCA1_pathway [accessed May 4, 2015].
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10711 http://dx.doi.org/10.1016/j.foodchem.2013.03.026
關聯:	Food Chemistry (Impact Factor: 3.26). 11/2013; 141(1):397-406.
显示于类别:	[生化微生物免疫研究所] 期刊論文

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