Association of plasminogen activators and matrix metalloproteinase-9 proteolytic cascade with blood-CNS barrier damage of angiostrongyliasis.

doi:10.1111/j.0959-9673.2006.00459.x

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/10668

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题名:	Association of plasminogen activators and matrix metalloproteinase-9 proteolytic cascade with blood-CNS barrier damage of angiostrongyliasis.
作者:	Chen, KM Liu, JY Lai, SC Hsu, LS Lee, HH
贡献者:	中山醫學大學
日期:	2006
上传时间:	2015-04-20T09:21:55Z (UTC)
ISSN:	0959-9673
摘要:	Blood-central nervous system (blood-CNS) barrier breakdown, an important pathophysiological event in meningitis, results in extravasation of leucocytes into subarachnoid space. The blood-CNS barrier disruption is mediated by primarily two enzyme systems, the plasminogen activators (PAs) and matrix metalloproteinases (MMPs). The present study showed that the activities of tissue-type PA (tPA), urokinase-type activator (uPA) and MMP-9 in cerebrospinal-like fluid (CSF-like fluid) were significantly increased in mice with eosinophilic meningitis compared with uninfected mice. Eosinophilia significantly correlated with tPA, uPA and MMP-9 activities, and albumin concentration. In addition, when GM6001, a specific matrix metalloproteinase blocker, was injected into infected mice, MMP-9 activity and total protein concentrations declined from their preinjection highs. These results suggest that the PAs and MMP-9 proteolytic cascade may be associated with blood-CNS barrier disruption in eosinophilic meningitis caused by Angiostrongylus cantonensis.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10668 http://dx.doi.org/10.1111/j.0959-9673.2006.00459.x
關聯:	Int J Exp Pathol. 2006 Apr;87(2):113-9.
显示于类别:	[醫學系] 期刊論文

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