The upregulation of type I plasminogen activator inhibitor in oral submucous fibrosis.

doi:10.1016/S1368-8375(02)00123-9

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/10614

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题名:	The upregulation of type I plasminogen activator inhibitor in oral submucous fibrosis.
作者:	Yang, SF Hsieh, YS Tsai, CH Chou, MY Chang, YC
贡献者:	中山醫學大學
日期:	2003
上传时间:	2015-04-10T07:45:35Z (UTC)
ISSN:	1368-8375
摘要:	Type I plasminogen activator inhibitor (PAI-1) is a 50 kDa glycoprotein belonging to the serine protease superfamily. PAI-1 is consistently and dramatically upregulated in a variety of fibrotic diseases. The aim of this study was to compare PAI-1 expression in normal human buccal mucosa and oral submucous fibrosis (OSF) specimens and further explore the potential mechanism that may lead to induced PAI-1 expression. Twenty-five OSF specimens and six normal buccal mucosa were examined by immunohistochemistry. The activity of PAI-1 from cells cultured from OSF and normal buccal mucosa were assayed using reverse-transcriptase polymerase chain reaction (RT-PCR) and Western blots. PAI-1 expression was significantly higher in OSF specimens and expressed mainly by fibroblasts, endothelial cells, and inflammatory cells. In addition, OSF exhibited higher PAI-1 expression than normal buccal mucosa fibroblast (BMF) both in mRNA and protein levels. To verify whether arecoline, a major areca nut alkaloid, could affect PAI-1 expression by human BMFs, RT-PCR and Western blots were used. The results demonstrated highly elevated PAI-1 mRNA and protein expression in normal human BMFs stimulated by arecoline. Taken together, these results suggest that PAI-1 expression is significantly upregulated in OSF tissues from areca quid chewers, and arecoline may be responsible for the enhanced PAI-1 expression in vivo. Copyright 2003 Elsevier Science Ltd.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10614 http://dx.doi.org/10.1016/S1368-8375(02)00123-9
關聯:	Oral Oncol. 2003 Jun;39(4):367-72.
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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