The tumor promoting effect of lime-piper betel quid in JB6 cells

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/10606

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题名:	The tumor promoting effect of lime-piper betel quid in JB6 cells
作者:	Lina, Ming-Hsun Choua, Fen-Pi Huanga, Hui-Pei Hsub, Jeng-Dong Chouc, Ming-Yung Wanga, Chau-Jong
贡献者:	中山醫學大學
关键词:	Tumor promoting effect;Lime-piper betel quid;Cytotoxicity;Type III foci
日期:	2003
上传时间:	2015-04-10T07:26:39Z (UTC)
ISSN:	0278-6915
摘要:	Betel quid chewing is a general behavior in Taiwan, India, southeastern Asian and South Africa. In this study, microculture tetrazolium test (MTT) showed that the extract of lime-piper betel quid (LPB) (1.0–20 mg/ml) was toxic to JB6 cells. Cells exposed of LPB (0.1, 0.5, 1.0 mg/ml) for 7 days resulted in changes in cytomorphology with characteristics of carcinogenesis. With a long-term treatment (∼30 days) of low doses of LPB (1, 5, 10 μg/ml), the production of H2O2 and the activity of myeloperoxidase (MPO) and ornithine decarboxylase (ODC) were increased in JB6 cells. Cell cycle analysis showed a decrease in the G1 phase and an accumulation in the S phase 48 h after LPB treatment. When treating with 0.5 mg/ml LPB for 15 days as a promoter, type III foci were formed in the JB6 culture. These results demonstrated the tumor promotional effect of LPB in JB6 cells.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10606 http://dx.doi.org/10.1016/S0278-6915(03)00124-8
關聯:	Food and Chemical Toxicology Volume 41, Issue 11, November 2003, Pages 1463–1471
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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