In vitro anti-microbial and in vivo cytokine modulating effects of different prepared Chinese herbal medicines.

doi:10.1016/j.fct.2006.07.010

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/10586

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10586

Title:	In vitro anti-microbial and in vivo cytokine modulating effects of different prepared Chinese herbal medicines.
Authors:	Lin, SJ Chen, CS Lin, SS Chou, MY Shih, HC Lee, IP Kao, CT Ho, CC Chen, FL Ho, YC Hsieh, KH Huang, CR Yang, CC
Contributors:	中山醫學大學
Date:	2006
Issue Date:	2015-04-10T04:50:57Z (UTC)
ISSN:	0278-6915
Abstract:	The toxicity, antimicrobial and cytokine modulating effects of herbal medicines in treating periodontal diseases were evaluated in this study. Using the broth dilution method and disc agar diffusion test, in individual and combined decocted preparations, different concentrations of Ching-Wei-San and its individual herbal components, Coptidis rhizoma, Angelicae sinensis radix, Rehmanniae radixet rhizom, Moutan radicis cortex, and Cimicifuga foetida, were tested for in vitro inhibitory effects on three well-known plaque-causing bacteria, Porphyromonas gingivialis, Streptococcus sanguis, and Streptococcus mutans, and two common pathogens, Staphylococcus aureus and Escherichia coli. The cytokine modulating effects were evaluated in Balb/c mice. The results suggested that one milliliter Ching-Wei-San at the 25,000 mg/mL concentration daily for the mice had significantly high levels in the liver function indexes in the 3-day acute toxicity test and in both the liver and kidney function indexes in the 28-day subacute toxicity test (P<0.01). The 250 mg/mL Ching-Wei-San is comparable to 250 mg/mL of tetracycline, and had similar inhibitory effects on the tested bacteria. Coptidis rhizoma (62.5 mg/mL) was the only individual herbal component to show 100% inhibitory effects. The mean cytokine ratios of IL-2, IL-4, IFN-gamma, and TNF-alpha in Balb/c mice treated with individual herbal components were shown to be different from each other. Ching-Wei-San modulated the immunity of mice, up-regulated IL-2, IL-4 and TNF-alpha, but down-regulated IFN-gamma. The effects of none of the individual herbal components alone can substitute for the cumulative effect of Ching-Wei-San.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10586 http://dx.doi.org/10.1016/j.fct.2006.07.010
Relation:	Food Chem Toxicol. 2006 Dec;44(12):2078-85. Epub 2006 Aug 7.
Appears in Collections:	[牙醫學系暨碩士班] 期刊論文

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