Epigallocatechin-3-gallate inhibits the invasion of human oral cancer cells and decreases the productions of matrix metalloproteinases and urokinase-plasminogen activator.

doi:10.1111/j.1600-0714.2007.00588.x

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/10583

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题名:	Epigallocatechin-3-gallate inhibits the invasion of human oral cancer cells and decreases the productions of matrix metalloproteinases and urokinase-plasminogen activator.
作者:	Ho, Yung-Chuan Yang, Shun-Fa Peng, Chih-Yu Chou, Ming-Yung Chang, Yu-Chao
贡献者:	中山醫學大學
关键词:	epigallocatechin-3-gallate;invasion;migration;matrix metalloproteinases;urokinase plasminogen activator
日期:	2007
上传时间:	2015-04-10T04:41:21Z (UTC)
ISSN:	0904-2512
摘要:	Background: Green tea polyphenols are considered beneficial to human health, especially as cancer chemopreventive agents in recent years. Epigallocatechin- 3-gallate (EGCG), the most abundant polyphenol in green tea, has been proven to suppress colonic tumorigenesis in animal and epidemiological studies, whereas its role in the oral carcinogenesis remains to be elucidated. Methods: Cytotoxicity, invasion, and migration assays were used to investigate the effects of human oral cancer cell line OC2 cells exposed to EGCG. To look at the precise involvement of EGCG in cancer metastasis, gelatin zymography and casein zymography were performed to evaluate the impacts of EGCG on matrix metalloproteinase (MMP)-2, MMP-9, and urokinase plasminogen activator (uPA) secretion in OC2 cells. Results: EGCG exhibited a dose-dependent inhibitory effect on the invasion and migration of OC2 cells in the absence of cytotoxicity (P < 0.05). EGCG was also found to decrease the expressions of MMP-2, MMP-9, and uPA in a concentration-dependent manner (P < 0.05). Conclusion: Taken together, these results suggest that EGCG could inhibit the invasion and migration of human oral cancer cells and that the effects may partially because of the decreased productions of MMP-2, MMP-9, and uPA.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10583 http://dx.doi.org/10.1111/j.1600-0714.2007.00588.x
關聯:	Journal of Oral Pathology & Medicine Volume 36, Issue 10, pages 588–593, November 2007
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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