中山醫學大學機構典藏 CSMUIR:Item 310902500/10534
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    题名: Correlation of immunoglobulin E, eosinophil cationic protein, and eosinophil count with the severity of childhood perennial allergic rhinitis.
    作者: Chen ST
    Sun HL
    Lu KH
    Lue KH
    Chou MC
    贡献者: 中山醫學大學
    日期: 2006-06
    上传时间: 2015-03-23T04:08:08Z (UTC)
    摘要: BACKGROUND AND PURPOSE:
    Elevated levels of serum total immunoglobulin E (IgE), serum allergen-specific IgE, serum eosinophil cationic protein (ECP), blood eosinophil count and nasal eosinophil count are considered to be associated with allergic rhinitis (AR), but the relationships between these allergic inflammatory markers and the clinical severity of AR remain controversial. This study aimed to clarify these relationships.
    METHODS:
    186 children aged 2 to 12 years old were selected, including 160 with perennial AR (PAR) and 26 with non-AR as controls. The total nasal symptom score was calculated for each patient from a questionnaire and correlated with data on serum total IgE, serum allergen-specific IgE, serum ECP, and eosinophil count in blood and nasal smear.
    RESULTS:
    Levels of all allergic inflammatory markers in children with PAR were significantly different from those in non-allergic children, except for serum ECP. All of the markers were related to the severity of PAR in bivariate correlation analysis. On multiple linear regression analysis, however, only nasal eosinophil count (p<0.001) and serum allergen-specific IgE (p=0.005) were independent predictors.
    CONCLUSION:
    These results suggest that nasal eosinophil count, an organ-specific allergic inflammatory marker, and serum allergen-specific IgE, a systemic allergic inflammatory marker, are correlated with the severity of PAR in children.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10534
    關聯: J Microbiol Immunol Infect. 2006 Jun;39(3):212-8.
    显示于类别:[醫學系] 期刊論文

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