Glucosamine sulfate suppresses the expressions of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis.

doi:10.1016/j.cca.2006.04.014

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/10504

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题名:	Glucosamine sulfate suppresses the expressions of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis.
作者:	Chu SC Yang SF Lue KH Hsieh YS Lee CY Chou MC Lu KH
贡献者:	中山醫學大學
关键词:	Glucosamine sulfate;Plasminogen activator;Inhibitor;Matrix metalloproteinase-2,-9;Osteoarthritis
日期:	2006-10
上传时间:	2015-03-18T05:42:38Z (UTC)
ISSN:	0009-8981
摘要:	BACKGROUND: Glucosamine sulfate may have an ex vivo inhibitory effect on the plasminogen activator (PA)/plasmin system and gelatinases expression during the early development of osteoarthritis (OA). METHODS: We compared the levels of urokinase-type PA (u-PA), PA inhibitor-1 (PAI-1) and gelatinases (matrix metalloproteinase-2 and -9 [MMP-2 and -9]) in a series of chondral, meniscal, and synovial cultures of early OA after treatment with or without glucosamine sulfate. RESULTS: Gelatin zymography revealed that glucosamine sulfate could suppress MMP-2 secretion in chondral, meniscal and synovial cultures and also decrease MMP-9 production in synovial and meniscal cultures. ELISA data also showed the suppressive effects of glucosamine sulfate on u-PA and PAI-1 production in synovial cultures at 48 h. CONCLUSIONS: Our data suggest that one of the therapeutic effects of glucosamine sulfate is to down-regulate the expressions of u-PA, PAI-1, MMP-2 and MMP-9 that underlie the destruction of articular cartilage in the early stage of OA, and therefore to delay the joint failure.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10504 http://dx.doi.org/10.1016/j.cca.2006.04.014
關聯:	Clin Chim Acta. 2006 Oct;372(1-2):167-72.
显示于类别:	[醫學系] 期刊論文

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