中山醫學大學機構典藏 CSMUIR:Item 310902500/10486
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    題名: Associations of serum leptin with atopic asthma and allergic rhinitis in children.
    作者: Quek YW
    Sun HL
    Ng YY
    Lee HS
    Yang SF
    Ku MS
    Lu KH
    Sheu JN
    Lue KH
    貢獻者: 中山醫學大學
    關鍵詞: Allergic rhinitis;asthma;atopy;body mass index;leptin;obesity;overweight
    日期: 2010-09
    上傳時間: 2015-03-16T10:46:10Z (UTC)
    ISSN: 1945-8924
    摘要: Abstract
    BACKGROUND:
    There is growing evidence of positive correlations between asthma (AS) and obesity in adults and children. Leptin is an obesity gene product secreted by white adipose tissue; elevated serum levels are found in obese adults and children. Recently, leptin has also been found to be associated with allergic rhinitis (AR). However, the links between serum leptin, atopic AS, and AR remained undetermined. Because AS and AR share common allergic inflammatory mechanisms, our aim was to determine if there were any differences in serum leptin levels between asthmatic children and nonasthmatic children with AR.
    METHODS:
    We studied 114 children (67 boys and 47 girls): 68 with mild intermittent-to-moderate persistent atopic AS (AS children) and 46 with mild-to-moderate persistent AR without AS (AR children; overall mean age, 8.51 years; range, 5-18 years). Body mass index (BMI), serum leptin, pulmonary function, and atopy parameters (serum IgE and eosinophil levels) were measured.
    RESULTS:
    Compared with AR children, AS children had higher body weights (kg), body mass indices (kg/cm²), and serum leptin levels (ng/mL). Multiple linear regression analyses showed that serum leptin concentrations differed significantly for girls, being overweight and between disease groups (AS and AR children).
    CONCLUSION:
    Our results indicate that a higher serum leptin level has stronger association with mild-to-moderate persistent AS compared with AR. Hence, serum leptin may be a stronger predictor for childhood AS compared with AR. Among the asthmatic children, higher serum leptin levels also showed stronger associations with female gender and being overweight.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10486
    http://dx.doi.org/10.2500/ajra.2010.24.3483
    關聯: Am J Rhinol Allergy. 2010 Sep-Oct;24(5):354-8
    顯示於類別:[醫學系] 期刊論文

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