中山醫學大學機構典藏 CSMUIR:Item 310902500/10485
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    题名: Cathepsin B and cystatin C play an inflammatory role in gouty arthritis of the knee.
    作者: Chu SC
    Yang SF
    Tzang BS
    Hsieh YS
    Lue KH
    Lu KH
    贡献者: 中山醫學大學
    关键词: Cathepsin B;Cystatin C;Gout;Inflammation;Knee
    日期: 2010-11
    上传时间: 2015-03-16T10:43:20Z (UTC)
    ISSN: 0009-8981
    摘要: BACKGROUND:
    To relate the expression of the matrix degrading proteinase cathepsin B and its endogenous inhibitor cystatin C in the synovial fluid (SF) to the clinical and laboratory variables of joint inflammation in gouty arthritis of the knee.
    METHODS:
    Thirty-nine SF samples were obtained from inflamed knees of patients with acute gout. The levels of cathepsin B, cystatin C, urokinase-type plasminogen activator (uPA), soluble uPA receptor (suPAR) and PA inhibitor type-1 (PAI-1), activities of matrix metalloproteinase-2 (MMP-2) and MMP-9, and cell counts as well as local arthritis activity scores (LAS) were examined.
    RESULTS:
    The increases of cathepsin B levels correlated with increased leukocyte and neutrophil counts, latent MMP-9 (pro-MMP-9) activities, uPA, suPAR and PAI-1 levels, and uPA/PAI-1 ratios. Increased cystatin C levels corresponded closely with increased LAS, leukocyte and neutrophil counts, pro-MMP-9 activities, uPA, suPAR and PAI-1 levels, and uPA/PAI-1 ratios. Moreover, there was a correlation between cathepsin B and cystatin C levels.
    CONCLUSIONS:
    These results show a high correlation between the cathepsin B/cystatin C system and markers of joint inflammation in acute gout of the knee, demonstrating the pathologic role of cathepsin B and cystatin C in inflammation.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10485
    http://dx.doi.org/10.1016/j.cca.2010.07.037
    關聯: Clin Chim Acta. 2010 Nov 11;411(21-22):1788-92
    显示于类别:[醫學系] 期刊論文

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