中山醫學大學機構典藏 CSMUIR:Item 310902500/10468
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    题名: Effect of the fungal immunomodulatory protein FIP-fve on airway inflammation and cytokine production in mouse asthma model.
    作者: Lee YT
    Lee SS
    Sun HL
    Lu KH
    Ku MS
    Ko JL
    Lue KH
    贡献者: 中山醫學大學
    关键词: Asthma;Chronic airway inflammation;Eosinophil;FIP-fve
    日期: 2013
    上传时间: 2015-03-16T08:21:19Z (UTC)
    ISSN: 1043-4666
    摘要: The allergy is dependent on the balance between Th1 and Th2. The fungal immunodulatory protein (FIP-fve) was isolated from Flammulina velutipes. FIP-fve has been demonstrated to skew the response to Th1 cytokine production. We investigated whether oral administrations of FIP-fve inhibited allergen (OVA)-induced chronic airway inflammation in the mouse asthma model. After intranasal challenge with OVA, the airway inflammation and hyperresponsiveness were determined by bronchoalveolar lavage fluid (BALF) analysis and ELISA assay. Both pre-treated and post-treated with FIP-fve suppressed the airway hyperresponsiveness by methacholine challenge and significantly decreased the number of infiltrating inflammatory cells and Th2 cytokines in bronchoalveolar lavage fluid (BALF) and serum compared with the OVA sensitized mice. In addition, FIP-fve reduced OVA-specific IgE levels in serum. FIP-fve markedly alleviated the OVA-induced airway hyperresponsiveness (AHR) to inhaled methacholine. Based on lung histopathological studies using hematoxylin and Liu's staining, FIP-fve inhibited inflammatory cell infiltration compared with the OVA-sensitized mice. Oral FIP-fve had an anti-inflammatory effect on OVA-induced airway inflammations and might posses the potential for alternative therapy for allergic airway diseases.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10468
    http://dx.doi.org/10.1016/j.cyto.2012.09.024
    關聯: Cytokine. 2013 Jan;61(1):237-44
    显示于类别:[醫學系] 期刊論文

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