Comparison of mometasone furoate monohydrate (Nasonex) and fluticasone propionate (Flixonase) nasal sprays in the treatment of dust mite-sensitive children with perennial allergic rhinitis.

doi:10.1016/j.pedneo.2013.01.007

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/10461

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题名:	Comparison of mometasone furoate monohydrate (Nasonex) and fluticasone propionate (Flixonase) nasal sprays in the treatment of dust mite-sensitive children with perennial allergic rhinitis.
作者:	Mak KK Ku MS Lu KH Sun HL Lue KH
贡献者:	中山醫學大學
关键词:	allergic rhinitis;eosinophil;fluticasone propionate;mometasone furoate monohydrate;nasal peak expiratory flow rate;Pediatric Rhinoconjunctivitis Quality of Life Questionnaire;total symptom score
日期:	2013-08
上传时间:	2015-03-16T05:04:36Z (UTC)
ISSN:	1875-9572
摘要:	Background Various studies have investigated the efficacies of mometasone furoate monohydrate (MFM) and fluticasone propionate (FP) nasal sprays for adults. However, research on their effectiveness for children is limited. This study compares the efficacies of MFM and FP nasal sprays in pediatric patients with perennial-allergic rhinitis. Materials and methods For this study, 94 perennial allergic rhinitis patients aged 6–12 years were randomly assigned to two treatment groups: an MFM group and an FP group. Treatment was provided for 4 weeks. The effects of the two agents were compared using the Pediatric Rhinoconjunctivitis Quality of Life Questionnaire and total symptom scores (TSSs). Nasal-peak expiratory flow rates and eosinophil percentage in nasal smears were also compared between the two groups. Results Patients in the MFM group exhibited significant improvement in their TSS (t = −2.65, p < 0.05). A detailed TSS analysis showed MFM to be more effective for relieving nasal symptoms, whereas FP was more effective for relieving non-nasal symptoms. Patient questionnaire scores suggested a significant reduction in symptoms for both the MFM (t = −7.23, p < 0.01) and FP (t = −5.43, p < 0.01) groups. The flow rate test results indicated significant improvements in the MFM group (t = 2.27, p < 0.05). Conclusion Following the 4-week therapy, MFM provided greater improvement compared to FP for symptoms of childhood perennial-allergic rhinitis. Based on their TSSs, the MFM group experienced more effective relief of nasal symptoms, whereas the FP group experienced more effective relief of non-nasal symptoms.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10461 http://dx.doi.org/10.1016/j.pedneo.2013.01.007
關聯:	Pediatr Neonatol. 2013 Aug;54(4):239-45.
显示于类别:	[醫學系] 期刊論文

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